Structure-Guided Directed Evolution of Highly Selective P450-Based Magnetic Resonance Imaging Sensors for Dopamine and Serotonin

Structure-Guided Directed Evolution of Highly Selective P450-Based Magnetic Resonance Imaging Sensors for Dopamine and Serotonin

New tools that allow dynamic visualization of molecular neural events are important for studying the basis of brain activity and disease. Sensors that permit ligand-sensitive magnetic resonance imaging (MRI) are useful reagents due to the noninvasive nature and good temporal and spatial resolution o...

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Bibliographic Details
Main Authors: Brustad, Eric M. (Author), Lelyveld, Victor S. (Contributor), Snow, Christopher D. (Author), Crook, Nathan (Author), Jung, Sang Taek (Author), Martinez, Francisco M. (Author), Scholl, Timothy J. (Author), Arnold, Frances H. (Author), Jasanoff, Alan Pradip (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Massachusetts Institute of Technology. Department of Nuclear Science and Engineering (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-10-27T12:51:57Z.
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