Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function

Tandem phosphorylation within an intrinsically disordered region regulates ACTN4 function

Phosphorylated residues occur preferentially in the intrinsically disordered regions of eukaryotic proteins. In the disordered amino-terminal region of human a-actinin-4 (ACTN4), Tyr[superscript 4] and Tyr[superscript 31] are phosphorylated in cells stimulated with epidermal growth factor (EGF), and...

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Main Authors: Travers, Timothy (Author), Shao, Hanshuang (Author), Wells, Alan (Author), Camacho, Carlos J. (Author), Joughin, Brian Alan (Author), Lauffenburger, Douglas A (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Joughin, Brian A. (Contributor), Lauffenburger, Douglas A. (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2015-10-29T14:07:26Z.
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