Single Dose Pharmacokinetics of Oral Tenofovir in Plasma, Peripheral Blood Mononuclear Cells, Colonic Tissue, and Vaginal Tissue

Single Dose Pharmacokinetics of Oral Tenofovir in Plasma, Peripheral Blood Mononuclear Cells, Colonic Tissue, and Vaginal Tissue

HIV seroconversion outcomes in preexposure prophylaxis (PrEP) trials of oral tenofovir (TFV)-containing regimens are highly sensitive to drug concentration, yet less-than-daily dosing regimens are under study. Description of TFV and its active moiety, TFV diphosphate (TFV-DP), in blood, vaginal tiss...

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Bibliographic Details
Main Authors: Louissaint, Nicolette A. (Author), Cao, Ying-Jun (Author), Skipper, Paul L. (Contributor), Liberman, Rosa G. (Contributor), Nimmagadda, Sridhar (Author), Anderson, Jean R. (Author), Everts, Stephanie (Author), Bakshi, Rahul (Author), Fuchs, Edward J. (Author), Hendrix, Craig W. (Author), Tannenbaum, Steven Robert (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. School of Science (Contributor)
Format: Article
Language:English
Published: Mary Ann Liebert, Inc., 2015-10-29T18:33:34Z.
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