Periodic retinoic acid-STRA8 signaling intersects with periodic germ-cell competencies to regulate spermatogenesis
Mammalian spermatogenesis-the transformation of stem cells into millions of haploid spermatozoa-is elaborately organized in time and space. We explored the underlying regulatory mechanisms by genetically and chemically perturbing spermatogenesis in vivo, focusing on spermatogonial differentiation, w...
Main Authors: | Endo, Tsutomu (Author), Romer, Katherine A. (Contributor), Anderson, Ericka L. (Contributor), Baltus, Andrew E. (Contributor), de Rooij, Dirk G. (Author), Page, David C (Author) |
---|---|
Other Authors: | Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Page, David C. (Contributor) |
Format: | Article |
Language: | English |
Published: |
National Academy of Sciences (U.S.),
2015-11-02T18:32:22Z.
|
Subjects: | |
Online Access: | Get fulltext |
Similar Items
-
Periodic production of retinoic acid by meiotic and somatic cells coordinates four transitions in mouse spermatogenesis
by: Endo, Tsutomu, et al.
Published: (2018) -
The Role of Stra8 in spermatogenesis : regulation of spermatogonial differentiation, meiotic initiation, and testicular tumor formation
by: Anderson, Ericka L. (Ericka Lynne)
Published: (2011) -
Retinoic Acid and Germ Cell Development in the Ovary and Testis
by: Endo, Tsutomu, et al.
Published: (2020) -
Overexpression of DAZL, STRA8, and BOULE Genes and Treatment With BMP4 or Retinoic Acid Modulate the Expression of MSC Overexpressing Germ Cell Genes
by: Paloma Cordero, et al.
Published: (2021-05-01) -
Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice.
by: Ianina C Ferder, et al.
Published: (2019-05-01)