Systematic Transfer of Prokaryotic Sensors and Circuits to Mammalian Cells

Systematic Transfer of Prokaryotic Sensors and Circuits to Mammalian Cells

Prokaryotic regulatory proteins respond to diverse signals and represent a rich resource for building synthetic sensors and circuits. The TetR family contains >10[superscript 5] members that use a simple mechanism to respond to stimuli and bind distinct DNA operators. We present a platform that e...

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Bibliographic Details
Main Authors: Stanton, Brynne C. (Contributor), Siciliano, Velia (Contributor), Wroblewska, Liliana (Contributor), Clancy, Kevin (Author), Trefzer, Axel C. (Author), Chesnut, Jonathan D. (Author), Weiss, Ron (Contributor), Voigt, Christopher A. (Contributor), Ghodasara, Amar Navin (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Synthetic Biology Center (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2015-11-20T13:21:25Z.
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