Systematic Transfer of Prokaryotic Sensors and Circuits to Mammalian Cells
Prokaryotic regulatory proteins respond to diverse signals and represent a rich resource for building synthetic sensors and circuits. The TetR family contains >10[superscript 5] members that use a simple mechanism to respond to stimuli and bind distinct DNA operators. We present a platform that e...
Main Authors: | Stanton, Brynne C. (Contributor), Siciliano, Velia (Contributor), Wroblewska, Liliana (Contributor), Clancy, Kevin (Author), Trefzer, Axel C. (Author), Chesnut, Jonathan D. (Author), Weiss, Ron (Contributor), Voigt, Christopher A. (Contributor), Ghodasara, Amar Navin (Contributor) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Synthetic Biology Center (Contributor) |
Format: | Article |
Language: | English |
Published: |
American Chemical Society (ACS),
2015-11-20T13:21:25Z.
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Subjects: | |
Online Access: | Get fulltext |
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