ATRX Directs Binding of PRC2 to Xist RNA and Polycomb Targets

ATRX Directs Binding of PRC2 to Xist RNA and Polycomb Targets

X chromosome inactivation (XCI) depends on the long noncoding RNA Xist and its recruitment of Polycomb Repressive Complex 2 (PRC2). PRC2 is also targeted to other sites throughout the genome to effect transcriptional repression. Using XCI as a model, we apply an unbiased proteomics approach to isola...

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Bibliographic Details
Main Authors: Sarma, Kavitha (Author), Cifuentes-Rojas, Catherine (Author), Ergun, Ayla (Author), Jeon, Yesu (Author), Sadreyev, Ruslan (Author), Lee, Jeannie T. (Author), White, Forest M. (Contributor), Del Rosario, Amanda M (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Del Rosario, Amanda M. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2015-11-20T13:57:33Z.
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