Total Syntheses of (+)-Geldanamycin, (-)-Ragaglitazar, and (+)-Kurasoin A and Phase-Transfer-Catalyzed Asymmetric Alkylation

Total Syntheses of (+)-Geldanamycin, (-)-Ragaglitazar, and (+)-Kurasoin A and Phase-Transfer-Catalyzed Asymmetric Alkylation

Geldanamycin possesses various biological activities as seen in the NCI 60 cell line panel (13 nM avg., 70 nM SKBr-3 cells). The predominant mode of action providing these unique results arises from the ability of geldanamycin (GA) to bind to the chaperone heat shock protein 90 (Hsp90). Despite its...

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Bibliographic Details
Main Author: Hicken, Erik J.
Format: Others
Published: BYU ScholarsArchive 2005
Subjects:
geldanamycin
ragaglitazar
kurasoin
phase transfer catalysis
PTC
asymmetric alkylation
cinchonidine
natural product
organic synthesis
Biochemistry
Chemistry
Online Access:https://scholarsarchive.byu.edu/etd/801
https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=1800&context=etd

Internet

https://scholarsarchive.byu.edu/etd/801
https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=1800&context=etd

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