An Adaptive Bayesian Approach to Bernoulli-Response Clinical Trials
Traditional clinical trials have been inefficient in their methods of dose finding and dose allocation. In this paper a four-parameter logistic equation is used to model the outcome of Bernoulli-response clinical trials. A Bayesian adaptive design is used to fit the logistic equation to the dose-res...
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ndltd-BGMYU2-oai-scholarsarchive.byu.edu-etd-24452021-09-01T05:01:21Z An Adaptive Bayesian Approach to Bernoulli-Response Clinical Trials Stacey, Andrew W. Traditional clinical trials have been inefficient in their methods of dose finding and dose allocation. In this paper a four-parameter logistic equation is used to model the outcome of Bernoulli-response clinical trials. A Bayesian adaptive design is used to fit the logistic equation to the dose-response curve of Phase II and Phase III clinical trials. Because of inherent restrictions in the logistic model, symmetric candidate densities cannot be used, thereby creating asymmetric jumping rules inside the Markov chain Monte Carlo algorithm. An order restricted Metropolis-Hastings algorithm is implemented to account for these limitations. Modeling clinical trials in a Bayesian framework allows the experiment to be adaptive. In this adaptive design batches of subjects are assigned to doses based on the posterior probability of success for each dose, thereby increasing the probability of receiving advantageous doses. Good posterior fitting is demonstrated for typical dose-response curves and the Bayesian design is shown to properly stop drug trials for clinical futility or clinical success. In this paper we demonstrate that an adaptive Bayesian approach to dose-response studies increases both the statistical and medicinal effectiveness of clinical research. 2007-08-06T07:00:00Z text application/pdf https://scholarsarchive.byu.edu/etd/1446 https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=2445&context=etd http://lib.byu.edu/about/copyright/ Theses and Dissertations BYU ScholarsArchive adaptive clinical trial Bayesian Metropolis-Hastings logistic model simulation Statistics and Probability |
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adaptive clinical trial Bayesian Metropolis-Hastings logistic model simulation Statistics and Probability |
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adaptive clinical trial Bayesian Metropolis-Hastings logistic model simulation Statistics and Probability Stacey, Andrew W. An Adaptive Bayesian Approach to Bernoulli-Response Clinical Trials |
description |
Traditional clinical trials have been inefficient in their methods of dose finding and dose allocation. In this paper a four-parameter logistic equation is used to model the outcome of Bernoulli-response clinical trials. A Bayesian adaptive design is used to fit the logistic equation to the dose-response curve of Phase II and Phase III clinical trials. Because of inherent restrictions in the logistic model, symmetric candidate densities cannot be used, thereby creating asymmetric jumping rules inside the Markov chain Monte Carlo algorithm. An order restricted Metropolis-Hastings algorithm is implemented to account for these limitations. Modeling clinical trials in a Bayesian framework allows the experiment to be adaptive. In this adaptive design batches of subjects are assigned to doses based on the posterior probability of success for each dose, thereby increasing the probability of receiving advantageous doses. Good posterior fitting is demonstrated for typical dose-response curves and the Bayesian design is shown to properly stop drug trials for clinical futility or clinical success. In this paper we demonstrate that an adaptive Bayesian approach to dose-response studies increases both the statistical and medicinal effectiveness of clinical research. |
author |
Stacey, Andrew W. |
author_facet |
Stacey, Andrew W. |
author_sort |
Stacey, Andrew W. |
title |
An Adaptive Bayesian Approach to Bernoulli-Response Clinical Trials |
title_short |
An Adaptive Bayesian Approach to Bernoulli-Response Clinical Trials |
title_full |
An Adaptive Bayesian Approach to Bernoulli-Response Clinical Trials |
title_fullStr |
An Adaptive Bayesian Approach to Bernoulli-Response Clinical Trials |
title_full_unstemmed |
An Adaptive Bayesian Approach to Bernoulli-Response Clinical Trials |
title_sort |
adaptive bayesian approach to bernoulli-response clinical trials |
publisher |
BYU ScholarsArchive |
publishDate |
2007 |
url |
https://scholarsarchive.byu.edu/etd/1446 https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=2445&context=etd |
work_keys_str_mv |
AT staceyandreww anadaptivebayesianapproachtobernoulliresponseclinicaltrials AT staceyandreww adaptivebayesianapproachtobernoulliresponseclinicaltrials |
_version_ |
1719473208055300096 |