Towards the Total Synthesis of Thioviridamide: Thiyl Radical Approach to the Beta-Thioenamide Linkage Formation
We developed an approach to the β-thioenamide linkage contained in the S-(2-aminovinyl)cysteine (avCys) residue of thioviridamide.1,2 Kinetic and thermodynamic control of radical additions of thiols to ynamides were studied for the formation of β-thioenamide linkage. Thiyl radicals are electrophilic...
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| Format: | Others |
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BYU ScholarsArchive
2008
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| Online Access: | https://scholarsarchive.byu.edu/etd/1950 https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=2949&context=etd |