Studies Toward Yaku'amide A and Synthesis and Applications of Bulky α,β-Dehydroamino Acids

Studies Toward Yaku'amide A and Synthesis and Applications of Bulky α,β-Dehydroamino Acids

Yaku'amide A shows a unique inhibitory profile against a series of 39 human cancer cell lines (JFCR39). In our efforts to synthesize yaku'amide A, we have optimized our regioselective base-free aminohydroxylation method with a series of nitrogen sources, developed a chiral reagent-mediated...

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Bibliographic Details
Main Author: Jiang, Jintao
Format: Others
Published: BYU ScholarsArchive 2016
Subjects:
yaku'amide A
inhibitory profile
chiral reagent-mediated aminohydroxylation
chemoselective deprotections
stereospecific E2 dehydration
right-hand tetrapeptide
NTA
bulky α
β-dehydroamino acids
ΔVal and ΔEnv
SPPS
analogues
Chemistry
Online Access:https://scholarsarchive.byu.edu/etd/6460
https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7460&context=etd

Internet

https://scholarsarchive.byu.edu/etd/6460
https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=7460&context=etd

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