Design, synthesis and biological evaluation of novel coumarinic derivatives as potential anticancer drugs Conception, synthèse et évaluation biologique de dérivés coumariniques en tant qu'agents anticancéreux potentiels

Design, synthesis and biological evaluation of novel coumarinic derivatives as potential anticancer drugs Conception, synthèse et évaluation biologique de dérivés coumariniques en tant qu'agents anticancéreux potentiels

3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate (IK9) was recently reported to be a potent inhibitor of cancer cell invasion and angiogenesis. It markedly reduced in vitro invasion of human HT1080 fibrosarcoma cells through collagen-coated porous membranes (Boyden chamber assay) an...

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Bibliographic Details
Main Author: Hemmer, Marc
Other Authors: PIROTTE, Bernard
Format: Others
Published: Universite de Liege 2010
Subjects:
Cancer
angiogenesis/angiogenese
proteases/proteases
coumarins/coumarines
drug development/developpement de molecules a visee therapeutique
tumor invasion/invasion tumorale
Online Access:http://bictel.ulg.ac.be/ETD-db/collection/available/ULgetd-11152010-182336/

Internet

http://bictel.ulg.ac.be/ETD-db/collection/available/ULgetd-11152010-182336/

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