Regulation of the tumor suppressor p53 by Mdm2 and Mdm4
Mdm2 and Mdm4 are critical negative regulators of the p53 tumor suppressor. Mdm4-null mutants are severely anemic and exhibit impaired proliferation of the fetal liver erythroid lineage cells. This phenotype may indicate a cell-intrinsic function of Mdm4 in erythropoiesis. In contrast, red blood cel...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Others |
| Language: | en |
| Published: |
Universite Libre de Bruxelles
2007
|
| Subjects: | |
| Online Access: | http://theses.ulb.ac.be/ETD-db/collection/available/ULBetd-01152008-232325/ |