Nucleoside Analogues that Mimic Water in the Minor Groove
Thesis advisor: Larry W. McLaughlin === Hydration in the minor groove of B-form DNA influences the stability and conformation of duplex DNA. An analogue nucleoside that attempts to mimic the N3-hydrated adenine was designed and synthesized. Obtaining the modified adenine was a significant synthetic...
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| Format: | Others |
| Language: | English |
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Boston College
2012
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| Online Access: | http://hdl.handle.net/2345/2909 |