Stabilized low-n amyloid-ß oligomers induce robust novel object recognition deficits associated with inflammatory, synaptic, and GABAergic dysfunction in the rat

Stabilized low-n amyloid-ß oligomers induce robust novel object recognition deficits associated with inflammatory, synaptic, and GABAergic dysfunction in the rat

Yes === Background:With current treatments for Alzheimer’s disease (AD) only providing temporary symptomatic benefits, disease modifying drugs are urgently required. This approach relies on improved understanding of the early pathophysiology of AD. A new hypothesis has emerged, in which early memory...

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Bibliographic Details
Main Authors: Watremez, W., Jackson, J., Almari, B., McLean, Samantha L., Grayson, B., Neilla, J.C., Fischer, N., Allouche, A., Koziel, V., Pillot, T., Harte, M.K.
Language:en
Published: 2018
Subjects:
Alzheimer’s disease
Amyloid-β oligomers
Cognition
Parvalbumin
Interneurons
Online Access:http://hdl.handle.net/10454/15087

Internet

http://hdl.handle.net/10454/15087

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