Mechanistic Insights into the Stabilisation of Biopharmaceuticals using Glycine Derivatives. The Effect of Glycine Derivatives on the Crystallisation, Physical Properties and Behaviour of Commonly used Excipients to Stabilise Antigens, Adjuvants and Proteins in the Solid State

Mechanistic Insights into the Stabilisation of Biopharmaceuticals using Glycine Derivatives. The Effect of Glycine Derivatives on the Crystallisation, Physical Properties and Behaviour of Commonly used Excipients to Stabilise Antigens, Adjuvants and Proteins in the Solid State

This dissertation has focused on studying the effect of four glycine derivatives on the solid state properties of mannitol, glycine, and sucrose when freeze dried into blended mixtures. The primary goal was to assess their value for use in the stabilisation of vaccines in the solid state, by examini...

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Bibliographic Details
Main Author: Bright, Andrew G.
Other Authors: Isreb, Mohammad
Language:en
Published: University of Bradford 2018
Subjects:
Freeze drying
Glycine derivatives
Differential scanning calorimetry (DSC)
Powder X-Ray diffraction (P-XRD)
Raman spectroscopy
Crystallisation
Water loss
Vaccines
Adjuvant
Stabilisation
Amorphous
Gordon-Taylor equation
Solubility parameters
Karl Fischer
Excipients
Proteins
DLS (Dynamic Light Scattering)
Polymorphs
Formulation
Mannitol
Sucrose
Biopharmaceuticals
Online Access:http://hdl.handle.net/10454/15943

Internet

http://hdl.handle.net/10454/15943

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