The temporal dynamics of Arc expression regulate cognitive flexibility

The temporal dynamics of Arc expression regulate cognitive flexibility

Yes === Neuronal activity regulates the transcription and translation of the immediate-early gene Arc/Arg3.1, a key mediator of synaptic plasticity. Proteasomedependent degradation of Arc tightly limits its temporal expression, yet the significance of this regulation remains unknown. We disrupt...

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Bibliographic Details
Main Authors: Wall, M.J., Collins, D.R., Chery, S.L., Allen, Z.D., Pastuzyn, E.D., George, A.J., Nikolova, V.D., Moy, S.S., Philpot, B.D., Shepherd, J.D., Muller, Jurgen, Ehlers, M.D., Mabb, A.M., Corrêa, Sonia A.L.
Language:en
Published: 2018
Subjects:
Arc/Arg3.1
Arc/Arg3.1 turnover
AMPA receptor trafficking
Synaptic plasticity
mGluR-LTD
Barnes maze
Reversal learning
Cognitive flexibility
Ubiquitin
Online Access:http://hdl.handle.net/10454/16201

Internet

http://hdl.handle.net/10454/16201

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