Validation of a voltage-sensitive dye (di-4-ANEPPS)-based method for assessing drug-induced delayed repolarisation in Beagle dog left ventricular midmyocardial myocytes

Validation of a voltage-sensitive dye (di-4-ANEPPS)-based method for assessing drug-induced delayed repolarisation in Beagle dog left ventricular midmyocardial myocytes

no === Evaluation of drug candidates in in-vitro assays of action potential duration (APD) is one component of preclinical safety assessment. Current assays are limited by technically-demanding, time-consuming electrophysiological methods. This study aimed to assess whether a voltage-sensitive dye-b...

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Bibliographic Details
Main Authors: Hardy, Matthew E., Pollard, C.E., Small, B.G., Bridgland-Taylor, M., Woods, A.J., Valentin, J.-P., Abi-Gerges, N.
Language:en
Published: 2018
Subjects:
Action potential duration
Cardiac ion channels
Dog species
IonWorks (TM)
Left ventricular midmyocardial myocytes
Methods
Voltage-sensitive dye
Online Access:http://hdl.handle.net/10454/16509

Internet

http://hdl.handle.net/10454/16509

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