Stereoselective production of dimethyl-substituted carbapenams via engineered carbapenem biosynthesis enzymes

Stereoselective production of dimethyl-substituted carbapenams via engineered carbapenem biosynthesis enzymes

Yes === Stereoselective biocatalysis by crotonase superfamily enzymes is exemplified by use of engineered 5-carboxymethylproline synthases (CMPSs) for preparation of functionalized 5-carboxymethylproline (5-CMP) derivatives methylated at two positions (i.e. C2/C6, C3/C6 and C5/C6), including product...

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Bibliographic Details
Main Authors: Hamed, Refaat B., Henry, L., Claridge, T.D.W., Schofield, C.
Language:en
Published: 2019
Subjects:
β-lactams
Protein engineering
Crotonases
Stereoselective biocatalysis
Antibiotic biosythesis
Online Access:http://hdl.handle.net/10454/17011

Internet

http://hdl.handle.net/10454/17011

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