Use of Methylmalonyl-CoA Epimerase in Enhancing Crotonase Stereoselectivity

Use of Methylmalonyl-CoA Epimerase in Enhancing Crotonase Stereoselectivity

Yes === The use of methylmalonyl-CoA epimerase (MCEE) to improve stereoselectivity in crotonase-mediated biocatalysis is exemplified by the coupling of MCEE, crotonyl-CoA carboxylase reductase and carboxymethylproline synthase in a three-enzyme one-pot sequential synthesis of functionalised C-5 carb...

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Bibliographic Details
Main Authors: Hamed, Refaat B., Gomez-Castellanos, J.R., Sean Froese, D., Krysztofinska, E., Yue, W.W., Schofield, C.J.
Language:en
Published: 2019
Subjects:
Antibiotics
Biosynthesis
Carbapenem
Crotonases
Dynamic kinetic discrimination
Enolate reactivity
Stereoselectivity
Online Access:http://hdl.handle.net/10454/17012

Internet

http://hdl.handle.net/10454/17012

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