In Vivo Selectivity and Localization of Reactive Oxygen Species (ROS) Induction by Osmium Anticancer Complexes That Circumvent Platinum Resistance

Yes === Platinum drugs are widely used for cancer treatment. Other precious metals are promising, but their clinical progress depends on achieving different mechanisms of action to overcome Pt-resistance. Here, we evaluate 13 organo-Os complexes: 16-electron sulfonyl-diamine catalysts [(η6-arene)Os(...

Full description

Bibliographic Details
Main Authors: Coverdale, J.P.C., Bridgewater, H.E., Song, J.-I., Smith, N.A., Barry, Nicolas P.E., Bagley, I., Sadler, P.J., Romero-Canelon, I.
Language:en
Published: 2019
Subjects:
ROS
Online Access:http://hdl.handle.net/10454/17070