Relative Bio-Equivalence of Salbutamol MDIs Without and With the Attached Spacers. Development and validation of novel HPLC methods for the determination of salbutamol (and terbutaline) in urine excreted post-inhalation for bioequivalence and pharmacokinetic studies of Salbutamol MDIs

Relative Bio-Equivalence of Salbutamol MDIs Without and With the Attached Spacers. Development and validation of novel HPLC methods for the determination of salbutamol (and terbutaline) in urine excreted post-inhalation for bioequivalence and pharmacokinetic studies of Salbutamol MDIs

This research explored in-vitro and in-vivo performance of three salbutamol metered dose inhalers (MDIs): Ventolin Evohaler (Evo), Airomir (Airo) and Salamol. In the in-vitro studies, critical quality attributes of the MDI using an Andersen cascade impactor (ACI) were examined and included measureme...

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Bibliographic Details
Main Author: Mazhar, Syed H.R.
Other Authors: Assi, Khaled H.
Language:en
Published: University of Bradford 2019
Subjects:
Salbutamol
Metered dose inhalers (MDIs)
Hydrofluoroalkane (HFA)
Bioequivalence
Urinary Pharmacokinetics
HPLC
SPE
Spacer
Charcoal block
In-Vitro equivalence
Fine particle dose (FPD)
Total delivered dose (TDD)
Online Access:http://hdl.handle.net/10454/17140

Internet

http://hdl.handle.net/10454/17140

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