Cellular uptake and efflux of palbociclib in vitro in single cell and spheroid models

Cellular uptake and efflux of palbociclib in vitro in single cell and spheroid models

Yes === Adequate drug distribution through tumours is essential for treatment to be effective. Palbociclib is a cyclin-dependent kinase (CDK) 4/6 inhibitor approved for use in patients with hormone receptor (HR) positive, HER2 negative metastatic breast cancer (BC). It has unusual physicochemical pr...

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Bibliographic Details
Main Authors: Jove, M., Spencer, Jade A., Hubbard, M.E., Holden, E.C., O'Dea, R.D., Brook, B.S., Phillips, Roger M., Smye, S.W., Loadman, Paul M., Twelves, C.J.
Language:en
Published: 2019
Subjects:
Cancer
Drug efflux
Mass spectrometry
Mathematical modeling
Pharmacokinetic/pharmacodynamic modeling
Online Access:http://hdl.handle.net/10454/17174

Internet

http://hdl.handle.net/10454/17174

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