Therapeutic Targeting of BMP and TGF-β Signalling Pathways for the Resolution of Pulmonary Arterial Hypertension

Therapeutic Targeting of BMP and TGF-β Signalling Pathways for the Resolution of Pulmonary Arterial Hypertension

Vascular remodelling due to excessive proliferation and apoptosis resistance of pulmonary arterial smooth muscle (PASMCs) and endothelial cells (ECs) has been attributed to the pathogenesis of pulmonary arterial hypertension (PAH). It is an incurable cardiovascular disorder, which leads to right...

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Bibliographic Details
Main Author: Sharmin, Nahid
Other Authors: Nasim, Md. Talat
Language:en
Published: University of Bradford 2019
Subjects:
Pulmonary arterial hypertension (PAH)
Bone morphogenetic protein (BMP)
Bone morphogenetic protein receptor type II (BMPR2)
Transforming growth factor β (TGF-β)
Pulmonary arterial smooth muscle cell
Endothelial cell
Cryptolepine
Inhibitor of differentiation
Plasminogen activator inhibitor
Apoptosis
Proliferation
Therapeutic intervention
Online Access:http://hdl.handle.net/10454/17177

Internet

http://hdl.handle.net/10454/17177

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