Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity

Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity

Yes === Tetrahydroisoquinoline (THIQ) is a key structural component in many biologically active molecules including natural products and synthetic pharmaceuticals. Here, we report on the use of transition-metal mediated [2 + 2 + 2] cyclotrimerisation of alkynes to generate tricyclic THIQs with poten...

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Bibliographic Details
Main Authors: Santos, Ana R.N., Sheldrake, Helen M., Ibrahim, Ali I.M., Danta, Chhanda C., Bonanni, D., Daga, M., Oliaro-Bosso, s., Boschi, D., Lolli, M.L., Pors, Klaus
Language:en
Published: 2019
Subjects:
Tetrahydroisoquinoline
THIQ
Online Access:http://hdl.handle.net/10454/17252

Internet

http://hdl.handle.net/10454/17252

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