Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity

Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity

Yes === Tetrahydroisoquinoline (THIQ) is a key structural component in many biologically active molecules including natural products and synthetic pharmaceuticals. Here, we report on the use of transition-metal mediated [2 + 2 + 2] cyclotrimerisation of alkynes to generate tricyclic THIQs with poten...

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Main Authors: Santos, Ana R.N., Sheldrake, Helen M., Ibrahim, Ali I.M., Danta, Chhanda C., Bonanni, D., Daga, M., Oliaro-Bosso, s., Boschi, D., Lolli, M.L., Pors, Klaus
Language:en
Published: 2019
Subjects:
Tetrahydroisoquinoline
THIQ
Online Access:http://hdl.handle.net/10454/17252
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spelling ndltd-BRADFORD-oai-bradscholars.brad.ac.uk-10454-172522020-07-15T07:09:31Z Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity Santos, Ana R.N. Sheldrake, Helen M. Ibrahim, Ali I.M. Danta, Chhanda C. Bonanni, D. Daga, M. Oliaro-Bosso, s. Boschi, D. Lolli, M.L. Pors, Klaus Tetrahydroisoquinoline THIQ Yes Tetrahydroisoquinoline (THIQ) is a key structural component in many biologically active molecules including natural products and synthetic pharmaceuticals. Here, we report on the use of transition-metal mediated [2 + 2 + 2] cyclotrimerisation of alkynes to generate tricyclic THIQs with potential to selectively inhibit AKR1C3. Fundação para a Ciência, a Tecnologia (PhD studentship ARNS SFRH/BD/46871/2008), EPSRC (RCUK Academic Fellowship HMS), UniTO grant Ricerca Locale 2015 (grant number LOLM_RILO_17_01) and Fondazione Cassa di Risparmio di Torino (grant BOSD_CRT_17_2). 2019-09-04T13:03:41Z 2019-09-24T13:25:37Z 2019-09-04T13:03:41Z 2019-09-24T13:25:37Z 2019-01 2019-06-27 2019-06-27 2019-09-04T12:03:44Z Article Accepted manuscript Santos ARN, Sheldrake HM, Ibrahim AIM et al (2019) Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity. MedChemComm. 10(8): 1476-1480. http://hdl.handle.net/10454/17252 en https://doi.org/10.1039/C9MD00201D (c) 2019 RSC. Full-text reproduced in accordance with the publisher's self-archiving policy.
collection NDLTD
language en
sources NDLTD
topic Tetrahydroisoquinoline
THIQ
spellingShingle Tetrahydroisoquinoline
THIQ
Santos, Ana R.N.
Sheldrake, Helen M.
Ibrahim, Ali I.M.
Danta, Chhanda C.
Bonanni, D.
Daga, M.
Oliaro-Bosso, s.
Boschi, D.
Lolli, M.L.
Pors, Klaus
Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity
description Yes === Tetrahydroisoquinoline (THIQ) is a key structural component in many biologically active molecules including natural products and synthetic pharmaceuticals. Here, we report on the use of transition-metal mediated [2 + 2 + 2] cyclotrimerisation of alkynes to generate tricyclic THIQs with potential to selectively inhibit AKR1C3. === Fundação para a Ciência, a Tecnologia (PhD studentship ARNS SFRH/BD/46871/2008), EPSRC (RCUK Academic Fellowship HMS), UniTO grant Ricerca Locale 2015 (grant number LOLM_RILO_17_01) and Fondazione Cassa di Risparmio di Torino (grant BOSD_CRT_17_2).
author Santos, Ana R.N.
Sheldrake, Helen M.
Ibrahim, Ali I.M.
Danta, Chhanda C.
Bonanni, D.
Daga, M.
Oliaro-Bosso, s.
Boschi, D.
Lolli, M.L.
Pors, Klaus
author_facet Santos, Ana R.N.
Sheldrake, Helen M.
Ibrahim, Ali I.M.
Danta, Chhanda C.
Bonanni, D.
Daga, M.
Oliaro-Bosso, s.
Boschi, D.
Lolli, M.L.
Pors, Klaus
author_sort Santos, Ana R.N.
title Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity
title_short Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity
title_full Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity
title_fullStr Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity
title_full_unstemmed Exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1C3 target affinity
title_sort exploration of [2 + 2 + 2] cyclotrimerisation methodology to prepare tetrahydroisoquinoline-based compounds with potential aldo-keto reductase 1c3 target affinity
publishDate 2019
url http://hdl.handle.net/10454/17252
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