Nucleosides Rescue Replication-Mediated Genome Instability of Human Pluripotent Stem Cells

Nucleosides Rescue Replication-Mediated Genome Instability of Human Pluripotent Stem Cells

Yes === Human pluripotent stem cells (PSCs) are subject to the appearance of recurrent genetic variants on prolonged culture. We have now found that, compared with isogenic differentiated cells, PSCs exhibit evidence of considerably more DNA damage during the S phase of the cell cycle, apparently as...

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Bibliographic Details
Main Authors: Ivana, Barbaric, Peter W, Andrews, Halliwell, J.A., Frith, T.J.R., Laing, O., Price, C.J., Bower, O.J., Stavish, T., Gokhale, P.J., Hewitt, Z., El-Khamisy, Sherif F.
Language:en
Published: 2020
Subjects:
Pluripotent
DNA
Damage
Replication
Stress
Nucleosides
Mitotic
Errors
Human
Online Access:http://hdl.handle.net/10454/18013

Internet

http://hdl.handle.net/10454/18013

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