The RAC1 target NCKAP1 plays a crucial role in progression of BRAF/PTEN -driven melanoma in mice
BRAF V600E is the most common driver mutation in human cutaneous melanoma and is frequently accompanied by loss of the tumor suppressing phosphatase PTEN. Recent evidence suggests a co-operative role for RAC1 activity in BRAF V600E -driven melanoma progression and drug resistance. However, the under...
Main Authors: | , , , , , , , , |
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Language: | en |
Published: |
2020
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Subjects: | |
Online Access: | http://hdl.handle.net/10454/18032 |