The RAC1 target NCKAP1 plays a crucial role in progression of BRAF/PTEN -driven melanoma in mice

The RAC1 target NCKAP1 plays a crucial role in progression of BRAF/PTEN -driven melanoma in mice

BRAF V600E is the most common driver mutation in human cutaneous melanoma and is frequently accompanied by loss of the tumor suppressing phosphatase PTEN. Recent evidence suggests a co-operative role for RAC1 activity in BRAF V600E -driven melanoma progression and drug resistance. However, the under...

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Bibliographic Details
Main Authors: Swaminathan, Karthic, Campbell, A., Papalazarou, V., Jaber-Hijazi, F., Nixon, C., McGhee, E., Strathdee, D., Sansom, O.J., Machesky, L.M.
Language:en
Published: 2020
Subjects:
Melanoma
Mice
RAC1
Online Access:http://hdl.handle.net/10454/18032

Internet

http://hdl.handle.net/10454/18032

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