Progress towards a clinically-successful ATR inhibitor for cancer therapy

Yes === The DNA damage response (DDR) is now known to play an important role in both cancer development and its treatment. Targeting proteins such as ATR (Ataxia telangiectasia mutated and Rad3-related) kinase, a major regulator of DDR, has demonstrated significant therapeutic potential in cancer tr...

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Bibliographic Details
Main Authors: Barnieh, Francis M., Loadman, Paul M., Falconer, Robert A.
Language:en
Published: 2021
Subjects:
DDR
ATR
ATM
Online Access:http://hdl.handle.net/10454/18345