Effects of phosphodiesterase inhibition on cortical spreading depression and associated changes in extracellular cyclic GMP.

No === Cortical spreading depression (CSD) is a temporary disruption of local ionic homeostasis that propagates slowly across the cerebral cortex, and may contribute to the pathophysiology of stroke and migraine. Previous studies demonstrated that nitric oxide (NO) formation promotes the repolarisat...

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Bibliographic Details
Main Authors: Urenjak, Jutta A., Fedele, E., Obrenovitch, Tihomir P., Wang, M.
Language:en
Published: 2009
Subjects:
Online Access:http://hdl.handle.net/10454/2784