Comparative Preclinical Pharmacokinetic and Metabolic Studies of the Combretastatin Prodrugs Combretastatin A4 Phosphate and A1 Phosphate.

Comparative Preclinical Pharmacokinetic and Metabolic Studies of the Combretastatin Prodrugs Combretastatin A4 Phosphate and A1 Phosphate.

Purpose: Combretastatin A4 phosphate (CA4P) and its structural analog, combretastatin A1 phosphate (CA1P), are soluble prodrugs capable of interacting with tubulin and causing rapid vascular shutdown within tumors. CA4P has completed Phase I clinical trials, but recent preclinical studies have shown...

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Bibliographic Details
Main Authors: Loadman, Paul M., Bibby, Michael C., Shnyder, Steven D., Swaine, David J., Kirwan, Ian G., Anthoney, Alan, Cooper, Patricia A., Lippert, J.W.
Language:en
Published: 2009
Subjects:
Combretastatin Prodrugs
Preclinical Pharmacokinetic
Tumors
Preclinical studies
Metabolism
Online Access:http://hdl.handle.net/10454/2953

Internet

http://hdl.handle.net/10454/2953

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