A Systematic Investigation into the Effect of Protein Destabilisation on Beta 2-Microglobulin Amyloid Formation

A Systematic Investigation into the Effect of Protein Destabilisation on Beta 2-Microglobulin Amyloid Formation

No === Beta-2-microglobulin (2m) has been shown to form amyloid fibrils with distinct morphologies under acidic conditions in vitro. Short, curved fibrils (<600 nm in length), form rapidly without a lag phase, with a maximum rate at pH 3.5. By contrast, fibrils with a long (~1 m), straight morpho...

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Bibliographic Details
Main Authors: Jones, Susan, Smith, D.P., Serpell, L.C, Sunde, M., Radford, S.E.
Language:en
Published: 2009
Subjects:
ß2-microglobulin
Amyloidosis
Stability
Intermediates
Thioflavin T
Online Access:http://hdl.handle.net/10454/3066

Internet

http://hdl.handle.net/10454/3066

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