Specific interaction of the diastereomers 7(R)- and 7(S)-tetrahydrobiopterin with phenylalanine hydroxylase: implications for understanding primapterinuria and vitiligo

Specific interaction of the diastereomers 7(R)- and 7(S)-tetrahydrobiopterin with phenylalanine hydroxylase: implications for understanding primapterinuria and vitiligo

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Pterin-4a-carbinolamine dehydratase (PCD) is an essential component of the phenylalanine hydroxylase (PAH) system, catalyzing the regeneration of the essential cofactor 6(R)-L-erythro-5,6,7,8-tetrahydrobiopterin [6(R)BH4]. Mutations in PCD or its deactivation by hydrogen peroxide result in the gener...

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Bibliographic Details
Main Authors: Schallreuter, Karin U., Maitland, Derek J., Pey, Angel L., Wood, John M., Calvo, Ana, Charubala, Ramamurthy, Martinez, Arurora, Pfleiderer, Wolfgang, Teigen, Knut
Language:en
Published: 2009
Subjects:
Pterin 4a-carbinolamine dehydtrase
NMR
Isothermal titration calirimetry
Online Access:http://hdl.handle.net/10454/3091

Internet

http://hdl.handle.net/10454/3091

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