Polar, Functionalized Guanine-O6 Derivatives Resistant to Repair by O6-Alkylguanine-DNA Alkyltransferase: Implications for the Design of DNA-modifying Drugs.

Polar, Functionalized Guanine-O6 Derivatives Resistant to Repair by O6-Alkylguanine-DNA Alkyltransferase: Implications for the Design of DNA-modifying Drugs.

No === The protein O6-alkylguanine-DNA alkyltransferase (Atase) is responsible for the repair of DNA lesions generated by several clinically important anti-cancer drugs; this is manifest as active resistance in those cancer cell lines proficient in Atase expression. Novel O6-substituted guanine anal...

Full description

Bibliographic Details
Main Authors: Wheelhouse, Richard T., Bibby, Michael C., Nicolaou, Anna, Pletsas, Dimitrios
Language:en
Published: 2009
Subjects:
Structure activity relation
Guanine derivatives
Competitive inhibition
Purine derivatives
Enzyme inhibitor
In vitro
Chemical synthesis
Enzyme
Transferases
DNA
Repair
Online Access:http://hdl.handle.net/10454/3168

Internet

http://hdl.handle.net/10454/3168

Similar Items