Chemical synthesis and biological evaluation of a NAD(P)H:quinone oxidoreductase-1-targeted tripartite quinone drug delivery system
No === NAD(P)H:quinone oxidoreductase-1 (NQO1) is a potential target for therapeutic intervention but attempts to exploit NQO1 using quinone-based bioreductive prodrugs have been largely compromised by toxicity to organs that inherently express high levels of NQO1. In an attempt to circumvent this p...
| Main Authors: | , , , , , , , , |
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| Language: | en |
| Published: |
2010
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| Subjects: | |
| Online Access: | http://hdl.handle.net/10454/4567 |