Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix-assisted laser desorption/ionisation mass spectrometry

Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix-assisted laser desorption/ionisation mass spectrometry

no === AQ4N (banoxatrone) (1,4-bis-{[2-(dimethylamino-N-oxide)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione) is an example of a bioreductive prodrug in clinical development. In hypoxic cells AQ4N is reduced to the topoisomerase II inhibitor AQ4 (1,4-bis- {[2-(dimethylamino)ethyl]amino}-5,8-dihydro...

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Bibliographic Details
Main Authors: Atkinson, S.J., Loadman, Paul M., Sutton, Chris W., Patterson, Laurence H., Clench, M.R.
Language:en
Published: 2010
Subjects:
Mass spectrometry
AQ4N
Bioreductive prodrug
Anti-tumor activity
Chemotherapy
MALDI-MSI
Online Access:http://hdl.handle.net/10454/4572

Internet

http://hdl.handle.net/10454/4572

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