NAD(P)H:Quinone oxidoreductase-1 C609T polymorphism analysis in human superficial bladder cancers: relationship of genotype status to NQO1 phenotype and clinical response to Mitomycin C.

NAD(P)H:Quinone oxidoreductase-1 C609T polymorphism analysis in human superficial bladder cancers: relationship of genotype status to NQO1 phenotype and clinical response to Mitomycin C.

NAD(P)H:Quinone oxidoreductase-1 (NQO1) has been implicated in the bioreductive activation of the clinically active anticancer drug Mitomycin C (MMC) and a polymorphic variant of NQO1 which lacks functional enzyme activity (NQO1*2) has been linked with poor survival in patients treated with MMC. The...

Full description

Bibliographic Details
Main Authors: Basu, Saurajyoti, Brown, John E., Flannigan, G. Michael, Gill, Jason H., Loadman, Paul M., Martin, Sandie W., Naylor, Brian, Puri, Rajiv, Scally, Andy J., Seargent, Jill M., Shah, Tariq K., Phillips, Roger M.
Language:en
Published: 2014
Subjects:
NAD(P)H:Quinone oxidoreductase-1 C609T
Mitomycin C (MMC)
Polymorphism analysis
Human superficial bladder cancers
Online Access:http://hdl.handle.net/10454/6401

Internet

http://hdl.handle.net/10454/6401

Similar Items