Design of ligands for sequence-specific recognition of the minor-major grooves of DNA

Design of ligands for sequence-specific recognition of the minor-major grooves of DNA

The two most powerful chemical approaches to date for the sequence-specific recognition of double helical DNA are the pyrrole-imidazole polyamides in the minor groove and oligonucleotide-directed triple-helix formation in the major groove. Described here are the design and synthetic methods to combi...

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Bibliographic Details
Main Author: Szewczyk, Jason W.
Format: Others
Language:en
Published: 1999
Online Access:https://thesis.library.caltech.edu/1531/1/Szewczyk_jw_1999.pdf
Szewczyk, Jason W. (1999) Design of ligands for sequence-specific recognition of the minor-major grooves of DNA. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/zt1g-kq41. https://resolver.caltech.edu/CaltechETD:etd-04282006-112749 <https://resolver.caltech.edu/CaltechETD:etd-04282006-112749>

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https://thesis.library.caltech.edu/1531/1/Szewczyk_jw_1999.pdf
Szewczyk, Jason W. (1999) Design of ligands for sequence-specific recognition of the minor-major grooves of DNA. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/zt1g-kq41. https://resolver.caltech.edu/CaltechETD:etd-04282006-112749 <https://resolver.caltech.edu/CaltechETD:etd-04282006-112749>

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