An Iterative Approach to de novo Computational Enzyme Design and the Successful Application to the Kemp Elimination
<p>The development of reliable methods for the 'on demand" de novo design of an enzymatic catalyst for an arbitrary chemical reaction has been an elusive goal of the computational protein design community. Recent successful results of de novo computational enzyme design have been en...
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https://thesis.library.caltech.edu/2175/10/HK_Privett_thesis.pdfhttps://thesis.library.caltech.edu/2175/11/Title.pdf
https://thesis.library.caltech.edu/2175/5/Chapter_1.pdf
https://thesis.library.caltech.edu/2175/6/Chapter_2.pdf
https://thesis.library.caltech.edu/2175/7/Chapter_3.pdf
https://thesis.library.caltech.edu/2175/8/Chapter_4.pdf
https://thesis.library.caltech.edu/2175/9/Chapter_4_figures.pdf
https://thesis.library.caltech.edu/2175/1/Appendix_A.pdf
https://thesis.library.caltech.edu/2175/2/Appendix_B.pdf
https://thesis.library.caltech.edu/2175/3/Appendix_C.pdf
https://thesis.library.caltech.edu/2175/4/Appendix_D.pdf
Privett, Heidi Kathleen (2009) An Iterative Approach to de novo Computational Enzyme Design and the Successful Application to the Kemp Elimination. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/1402-XZ32. https://resolver.caltech.edu/CaltechETD:etd-05272009-091024 <https://resolver.caltech.edu/CaltechETD:etd-05272009-091024>