Chemical-Scale Studies of the Nicotinic Acetylcholine Receptor: Insights from Amide-to-Ester Backbone Mutagenesis
<p>This thesis describes the use of peptide backbone amide-to-ester mutations to study the structure and function of ligand-gated ion channels. The research described herein has been done on the muscle nicotinic acetylcholine receptor, a prototypical ligand-gated ion channel in the cys-loop s...
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https://thesis.library.caltech.edu/5794/9/Thesis.pdfhttps://thesis.library.caltech.edu/5794/10/Table_of_Contents.pdf
https://thesis.library.caltech.edu/5794/2/Chapter1.pdf
https://thesis.library.caltech.edu/5794/3/Chapter2.pdf
https://thesis.library.caltech.edu/5794/4/Chapter3.pdf
https://thesis.library.caltech.edu/5794/5/Chapter4.pdf
https://thesis.library.caltech.edu/5794/6/Chapter_5.pdf
https://thesis.library.caltech.edu/5794/7/Chapter6.pdf
https://thesis.library.caltech.edu/5794/8/Chapter_7.pdf
Gleitsman, Kristin Rule (2010) Chemical-Scale Studies of the Nicotinic Acetylcholine Receptor: Insights from Amide-to-Ester Backbone Mutagenesis. Dissertation (Ph.D.), California Institute of Technology. doi:10.7907/ZYZF-9E22. https://resolver.caltech.edu/CaltechTHESIS:05102010-211900670 <https://resolver.caltech.edu/CaltechTHESIS:05102010-211900670>