Challenging Development of a Humanized Mouse Model for Evaluating the HTLV-1 Infection and Leukemogenic Process in vivo
Human T-cell Leukemia Virus type 1 (HTLV-1) is the etiologic agent of the Adult T-cell Leukemia (ATL), an aggressive lymphoproliferation of activated CD4+ T cells. The lack of a reliable small animal model to reproduce in vivo the leukemogenic process associated with HTLV-1 infection has impaired th...
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| Language: | ENG |
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Ecole normale supérieure de lyon - ENS LYON
2011
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| Online Access: | http://tel.archives-ouvertes.fr/tel-00682482 http://tel.archives-ouvertes.fr/docs/00/68/24/82/PDF/VILLAUDY_Julien_2011_These.pdf |