Creating and use of an new experimental preclinical HLA transgenic mice model to mapping HLA-restricted T cells epitopes for polyepitopes vaccine design.
A new homozygous humanized HLA transgenic mouse strain, HLA-A2.1+/+HLA-DP4+/+hCD4+/+mCD4-/-IAβ-/-β2m-/- (HLA-A2/DP4), was obtained by crossing the HLA transgenic HLA-A2.1+/+β2m-/-(A2) mice and HLA transgenic HLA-DP4+/+hCD4+/+mCD4-/-IAβ-/-(DP4) mice. In HLA-A2/DP4 mice, HLA-A2 restricted or HLA-DP4 r...
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| Language: | ENG |
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Université Paris Sud - Paris XI
2012
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| Online Access: | http://tel.archives-ouvertes.fr/tel-00714984 http://tel.archives-ouvertes.fr/docs/00/71/49/84/PDF/VA_RU_Zhitao_21022012.pdf |