Molecular mechanism of HIV-1 integrase inhibition by Raltegravir proposed by using of molecular modeling approaches
The HIV-1 integrase catalyzes the integration of HIV-1 viral DNA (vDNA) into the host cell chromosome in a process, which is essential for viral replication through two independent reactions, 3'-processing (3'-P) and strand transfer (ST), catalyzed by IN. Deciphering the structural determi...
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| Language: | ENG |
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École normale supérieure de Cachan - ENS Cachan
2012
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| Online Access: | http://tel.archives-ouvertes.fr/tel-00905951 http://tel.archives-ouvertes.fr/docs/00/90/59/51/PDF/Arora2012.pdf |