Primary T cell immunodeficiencies associated with disturbed proximal T cell receptor signalling caused by human autosomal recessive LCK, ZAP-70 and ITK-mutations
T lymphocytes express either a preTCR, or a clonotypic γδ TCR or αβ TCR together with the CD3-complex and the associated ζ-chain. TCR:CD3:ζ-signalling is crucial for T cell development and antigen-specific activation including proliferation, differentiation, effector functions and apoptosis of matur...
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| Language: | ENG |
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Université René Descartes - Paris V
2013
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| Online Access: | http://tel.archives-ouvertes.fr/tel-00937287 http://tel.archives-ouvertes.fr/docs/00/93/72/87/PDF/va_hauck_fabian.pdf |