Structural and functional study of efflux pumps involved in drug resistance
Resistance to chemotherapy is partly due to efflux pumps expressed in the plasma membrane which prevents the accumulation of anticancer, antiviral, antifungal and antibacterial drugs in target cells. Three human ABC transporters are particularly involved in MDR phenotype: P-gp/ABCB1, MRP1/ABCC1 and...
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| Language: | English |
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Université Claude Bernard - Lyon I
2014
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| Online Access: | http://tel.archives-ouvertes.fr/tel-00985593 http://tel.archives-ouvertes.fr/docs/00/98/55/93/PDF/TH2014_Martinez-Jaramillo_Lorena-Marcela.pdf |