CNI-1493 inhibits Aβ production, plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease
Alzheimer's disease (AD) is characterized by neuronal atrophy caused by soluble amyloid β protein (Aβ) peptide "oligomers" and a microglial-mediated inflammatory response elicited by extensive amyloid deposition in the brain. We show that CNI-1493, a tetravalent guanylhydrazone with e...
Main Authors: | , , , , , , , , , , , , , |
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Other Authors: | |
Format: | Article |
Language: | English |
Published: |
Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden
2012
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Online Access: | http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-100338 http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-100338 http://www.qucosa.de/fileadmin/data/qucosa/documents/10033/Bacher-et-al-2008.pdf |