Imbalance of SMC1 and SMC3 Cohesins Causes Specific and Distinct Effects

Imbalance of SMC1 and SMC3 Cohesins Causes Specific and Distinct Effects

SMC1 and SMC3 form a high-affinity heterodimer, which provides an open backbone of the cohesin ring, to be closed by a kleisin protein. RNAi mediated knock-down of either one heterodimer partner, SMC1 or SMC3, is expected to cause very similar if not identical phenotypes. However, we observed highly...

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Bibliographic Details
Main Authors: Laugsch, Magdalena, Seebach, Jochen, Schnittler, Hans, Jessberger, Rolf
Other Authors: Public Library of Science,
Format: Article
Language:English
Published: Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden 2014
Subjects:
Zytoplasma
Chromatin
TU Dresden
Publikationsfonds
Cytoplasm
chromatin
Cell cycle and cell division
DNA-binding proteins
Mutation
Protein extraction
Small interfering RNA
Transfection
Technical University Dresden
Publication funds
ddc:610
rvk:XA 10000
Online Access:http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-127228
http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-127228
http://www.qucosa.de/fileadmin/data/qucosa/documents/12722/journal.pone.0065149.pdf

Internet

http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-127228
http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-127228
http://www.qucosa.de/fileadmin/data/qucosa/documents/12722/journal.pone.0065149.pdf

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