Specific adaptations in the proteostasis network of the social amoebae Dictyostelium discoideum lead to an unusual resilience to protein aggregation

Specific adaptations in the proteostasis network of the social amoebae Dictyostelium discoideum lead to an unusual resilience to protein aggregation

A key prerequisite for cellular and organismal health is a functional proteome. A variety of human protein misfolding diseases are associated with the occurrence of amyloid protein aggregates, such as amyotrophic lateral sclerosis (ALS) or Huntington’s disease. The proteins involved in disease manif...

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Bibliographic Details
Main Author: Malinovska, Liliana
Other Authors: Technische Universität Dresden, Fakultät Mathematik und Naturwissenschaften
Format: Doctoral Thesis
Language:English
Published: Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden 2014
Subjects:
Protein Aggregation
Amyloide
Moleculare Chaperone
Proteostase
Dictyostelium discoideum
protein aggregation
amyloid
molecular chaperones
proteostasis
ddc:570
rvk:WD 5100
Online Access:http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-144848
http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-144848
http://www.qucosa.de/fileadmin/data/qucosa/documents/14484/Dissertation_Liliana%20Malinovska_2014pre.pdf

Internet

http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-144848
http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-144848
http://www.qucosa.de/fileadmin/data/qucosa/documents/14484/Dissertation_Liliana%20Malinovska_2014pre.pdf

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