The role of RNase H2 in genome maintenance and autoimmune disease
Aicardi-Goutières syndrome (AGS) is an autosomal recessive encephalopathy with low incidence. The disease is caused by mutations in the genes encoding for TREX1, SAMHD1, ADAR, IFIH1 and the three genes encoding for the heterotrimeric RNase H2 enzyme. Biallelic mutations in any of the genes cause ele...
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Format: | Doctoral Thesis |
Language: | English |
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Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden
2018
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Online Access: | http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-193520 http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-193520 http://www.qucosa.de/fileadmin/data/qucosa/documents/19352/doctoral_thesis_formatiert_final_final.pdf |