Changes of bivalent chromatin coincide with increased expression of developmental genes in cancer

Changes of bivalent chromatin coincide with increased expression of developmental genes in cancer

Bivalent (poised or paused) chromatin comprises activating and repressing histone modifications at the same location. This combination of epigenetic marks at promoter or enhancer regions keeps genes expressed at low levels but poised for rapid activation. Typically, DNA at bivalent promoters is only...

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Bibliographic Details
Main Authors: Bernhart, Stephan H., Kretzmer, Helene, Holdt, Lesca M., Jühling, Frank, Ammerpohl, Ole, Bergmann, Anke K., Northoff, Bernd H., Doose, Gero, Siebert, Reiner, Stadler, Peter F., Hoffmann, Steve
Other Authors: Universität Leipzig, Fakultät für Mathematik und Informatik
Format: Article
Language:English
Published: Universitätsbibliothek Leipzig 2016
Subjects:
Chromatin
Krebs
bivalent chromatin
cancer
ddc:601
Online Access:http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-215991
http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-215991
http://www.qucosa.de/fileadmin/data/qucosa/documents/21599/OAP-2016-187_Bernhart_srep37393.pdf

Internet

http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-215991
http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-215991
http://www.qucosa.de/fileadmin/data/qucosa/documents/21599/OAP-2016-187_Bernhart_srep37393.pdf

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